Sure, this things can be planned, and penalties are not that high, and missions can be taken at any time... it is just annoying when you take a mission (kill X pirates for example), partially complete it, then you have to go, and when you return a day or two later you basically have lost all your progress.From what I've seen the timers can range from 20 mins to 17 hours right up to a couple of days. As far as long range hauling goes, I'll take the short timers if I have time, or the 17 hour ones if I know I'm busy. It's not like the missions disappear if you don't select them. I've turned down plenty of of high paying missions because 2 hours is not enough time for me to get on with real life and come back to complete. No big deal, when I get home a new batch are waiting for me.
Also i just believe that any game need to have a way to exit it at any moment without penalties. Just because it is game... and it has nothing to do with it being "casual" or something...