Playing ED using a X52 Pro and i'm one of the 10%
Made a post a few months back trying to find out what it was that makes left handed people think it so hard to used a HOTAS thats been laid out Throttle on the left Stick on the right as I have been flying right handed for years.
What you need to remember unlike a single joystick the controls and buttons are split 50/50 between both hands and if you set it up right then the workload should be split about the same amount.
I have mine set up:
Right Hand: Weapons fire, general flight control (Roll, Pitch, Yaw), Targeting, and Menu navigation.
Left Hand: Throttle, fine flight control ( thrusters), weapons select and deployment, sub system navigation, scanner, power management , Hyperspace and boost keys.
In most cases ie combat both hands share the workload and im not trying to steer the ship, make fine adjustments, fire the weapons and set power levels all with the right hand on the stick leaving the left to just run the thrusters.
The only time my hand needs to leave the stick is to deploy the cargo scoop.