Personally I'm not averse to risk (nor combat), and presumably we wouldn't know what areas to avoid..
I'd imagine that getting caught in the blast of a supernova and having modules degraded could be a good game loop. But this would presume that you didn't make your homework when plotting your route, or that you actually go looking for it. Even in the Milkyway they aren't an hourly occurrence.
I think I mentioned environmental dangers in a past post, things like crumbling ground, quick sand, rock falls, avalanches, but this would mean much more work on the environment, and I'm not sure we are getting that any time soon..
Imagine to walk on an ice world and the ground breaks under your feet. You fall down and lose health, then you find some alien artifacts, and need 3 hours to find a way back to your ship.