Kerbal Space Program is fantastic, although I think it plays better on the keyboard.
G
While I've got a HOTAS setup, I play KSP with an Xbox controller. I don't like keyboard as having analog controls are useful, but the full HOTAS is too much trouble to "get into" as a lot of time is spent waiting for rendezvous and what not.
Amazing game. Gives me a real sense of accomplishment.