Well I tried a few times mining outside of RES sites, mining over 100 units without finding any painite (in stated hotspots), I then went to low threat RES sites next to them and started to find it, however even though I was surrounded by police and bounty hunters, I was pretty constantly set upon by pirates, until I luckily found advice online to fly about 40km from the entry point, to lose the pirates and still find painite...Yes mining is dull and I haven't bothered with it since unlocking Selene and Bill Turner (Yes unfortunately there is another one!). However selene merely required you to mine and refine 500 tonnnes. She said nothing about hauling it round so a sidewinder could have done that bit and just dumped the results back where you found them. Much quicker and less painful.
The final 10 tonnes of Painite are a bit harder to locate but not that hard. Doing it in a High Sec system should also reduce the pirate traffic.
Which indeed I did, after unfortunately being hassled by pirates quite a lot before I knew to do that...
Long story short, as far as I can see, the pirates don't care about the local security state, but only the 40km journey!! .
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