Hard to give complete advice if we don't know the OS and game platform etc

Nothing in ED does that kind of macroing, and the only fixes on the patch notes were to add the ability to use the controller on certain screens, which doesn't sound like what you are experiencing.
If you're running it from Steam, see if Steam Input is doing something funky with the button mappings, or just keeping the Steam Desktop settings instead of letting the game through, almost as if it just isn't recognising the game as running?