Prepare for some crazy:
"OTSEAFOTSEAF" and the 'Cor meum et animam' tie in are the new clues.
EAFOTS is a region of space beyond the heart and soul nebula, and the heart and soul is fairly squarely pointed at by the ship name.
Except those aren't new clues, given that we have already checked the H&S and know that the region beyond it is a likely place to search. So the 'new' clues don't tell us anything new.
Unless they do.
OTSEAFOTSEAF stands out as being easily rearranged into: Feast of 'aesto' or an anagram of those five letters, or 'East of 'aestof'.... which could also be 'east of' again: 'East of East of' doesn't make too much sense, though... at least not in an immediate and useful manner. However, 'ostra' and 'eastra' struck me as also being pretty close to spelling variations of a pagan god (and we all know how pagan mythology plays into this a bit) and origin of the word 'Easter'. Well, there was certainly historically a feast of Easter. In more modern times, I certainly know what my feast of Easter is:
Easter Eggs.
Which of course has the double meaning of 'something hidden in a game'.
Are we looking for a feast of easter: An 'egg'
This is wild speculation without it leading somewhere of course. Which is why I am sat out here checking systems called 'EAFOTS EG-G'. Surprisingly, there are some. Trying to narrow it down further without going there physically would be pure numerology, and I'm not going to go down that route.
There is a suspicious cluster of them just past the H&S and squarely between them if you consider the nebulae to be a 'gateway' to the sector. So I went there to check out B24-0, B24-1, B24-2, B24-3... nothing remarkable, though a few things that made me check the systems properly. A staller smiley face is looking down and taunting me, though.
I've also checked B11-0, B40-0, B52-1, B52-0, B39-0, C26-0
There are more 'egg' systems, but all are considerably further into out and very widely spread:
EDIT: All Eggs now checked! No luck.