The main issue I see with the global supply chain I have labelled the Guinness Syndrome. International shipments of Guinness stout has been going out of Dublin for ages, but now there's a number of hurdles to these: Brexit first, perhaps (Brexit Troubles). However, snarls in the bulk surface freight chains are not helping things either. The result is that here in NZ, with only 20 new cases of the Delta variant yesterday, we can get Black Sheep and other interesting brews from Old Blightey. But not Guinness.
Which is a shame. I use Guinness for baking. It gives a nice savoury flavour to sourdough rye bread. It also is a nice side to a glass of Dimple whisky when I'm roasting coffee. Yes, I'm at 85% hipster and rising.
In the Upper Right, the light colour shows high concentrations in severe cases.
In the Lower Left, the light colour shows high concentrations of different chemicals in mild cases.
So what does this tell us?
In mild cases, Glucose is low, and Glutamine is high. Humans are not making glucose out of glutamine.
In mild cases, Amino acids(pale green names) are high. Protein isn't being broken down.
In mild cases, there are also almost no ketones in the plasma. Fat mass is being left alone.
In the hospitalized cases, different story. Glucose is sky high. Where is it coming from? Protein breakdown, as the amino acids go almost to zero. Why is the body obsessed with making so much glucose? Because remember, the mitochondria are switched off as there's little oxygen, and HIF-1alpha gets made. So enormous amounts of glucose are being used for very little energy output. It's virtual starvation going on, with protein breakdown to amino acids almost depleted for energy, and fats going to make b-hydroxybutyrate.
This situation is akin to running a starship without its main power supply. Just as we use aux sources of energy to keep going there, we can do the same here.
If we accelerate the fats breakdown to acyl co-A , we can get power from beta-oxidation pathway. That would slow down all the destruction going on to make more glucose.
From general knowledge:
Fibrates also enhance fatty acid oxidation via acyl CoA synthetase and other enzymes, which further reduce the synthesis of triglycerides.
The SARS-CoV-2 virus has infected over 165 million people worldwide causing nearly 3.5 million deaths. Recent vaccination efforts have been hindered by multiple coronavirus variants that challenge current vaccines.
www.news-medical.net
...the patients were given 145 mg/day of TriCor (fenofibrate) for 10 days and continuously monitored for disease progression and outcomes. "The results were astounding", shared Nahmias. "Progressive inflammation markers, that are the hallmark of deteriorative COVID-19, dropped within 48 hours of treatment. Moreover, 14 of the 15 severe patients didn't require oxygen support within a week of treatment,
The theory is foundationally rock solid.
Instead of buying Ivermectin, this is what people ought to be looking at. FENOFIBRATE.
Also, supplementing the mitochondria directly with l-Carnitine to move the fats in, plus alpha-ketoglutarate to kickstart Krebs cycle( it will be short, as it's shunted to make glutamate for energy), and supplementing glutamine IV. These are normal metabolites, which pose no hazard, as our bodies generate them all the time. I still feel that the use of Apigenin is logical since it blocks HIF-1 alpha, and will conserve NAD via inhibiting CD 38, an important energy cofactor.
There's a minor pathway to breakdown fats in peroxisomes, which uses acyl-CoA too, but it makes a lot of peroxide. It would probably be a good idea to supply NAC and glycine to make glutathione to mop up that excess oxidation. Chances are the peroxisome pathway might be accelerated if mitochondria are stalled out.
In New Zealand we had 21 new COVID cases in the community today. So that's basically a flat curve for the last 3 - 4 days. No new cases outside existing clusters, but there are still 24 'mystery cases' without links to these clusters.
Tonight at midnight most of the country goes to Level 2, while Auckland stays locked in Level 4. That means Northland is even more cut off from the rest of the country, as the only way out of that region on land is by driving through Plague City.
Generally it is going well. Tomorrow will be my first take-out night in months. I look forward to it, somewhat.
In the Upper Right, the light colour shows high concentrations in severe cases.
In the Lower Left, the light colour shows high concentrations of different chemicals in mild cases.
So what does this tell us?
In mild cases, Glucose is low, and Glutamine is high. Humans are not making glucose out of glutamine.
In mild cases, Amino acids(pale green names) are high. Protein isn't being broken down.
In mild cases, there are also almost no ketones in the plasma. Fat mass is being left alone.
In the hospitalized cases, different story. Glucose is sky high. Where is it coming from? Protein breakdown, as the amino acids go almost to zero. Why is the body obsessed with making so much glucose? Because remember, the mitochondria are switched off as there's little oxygen, and HIF-1alpha gets made. So enormous amounts of glucose are being used for very little energy output. It's virtual starvation going on, with protein breakdown to amino acids almost depleted for energy, and fats going to make b-hydroxybutyrate.
This situation is akin to running a starship without its main power supply. Just as we use aux sources of energy to keep going there, we can do the same here.
If we accelerate the fats breakdown to acyl co-A , we can get power from beta-oxidation pathway. That would slow down all the destruction going on to make more glucose.
From general knowledge:
The SARS-CoV-2 virus has infected over 165 million people worldwide causing nearly 3.5 million deaths. Recent vaccination efforts have been hindered by multiple coronavirus variants that challenge current vaccines.
www.news-medical.net
The theory is foundationally rock solid.
Instead of buying Ivermectin, this is what people ought to be looking at. FENOFIBRATE.
Also, supplementing the mitochondria directly with l-Carnitine to move the fats in, plus alpha-ketoglutarate to kickstart Krebs cycle( it will be short, as it's shunted to make glutamate for energy), and supplementing glutamine IV. These are normal metabolites, which pose no hazard, as our bodies generate them all the time. I still feel that the use of Apigenin is logical since it blocks HIF-1 alpha, and will conserve NAD via inhibiting CD 38, an important energy cofactor.
There's a minor pathway to breakdown fats in peroxisomes, which uses acyl-CoA too, but it makes a lot of peroxide. It would probably be a good idea to supply NAC and glycine to make glutathione to mop up that excess oxidation. Chances are the peroxisome pathway might be accelerated if mitochondria are stalled out.
Healthy people burn glucose with oxygen, and make CO2 and water, to produce most of the energy.
During Covid Pneumonia, there's an oxygen shortage. Mitochondria shut down, toggled by Hypoxia Inducible Factor-1 alpha.
The only source of power is glucose breakdown to lactic acid. It's terribly small. To stay alive, we need giant amounts of glucose. So we break down muscle to get it.
So how is our immune system supposed to fight an infection, when we barely have power for life support? I'm talking like the heartbeat.
There's none for shields and guns. The ship can barely fly. If we could source extra power we might be able to do a lot better.
Well, other than carbs and protein, we also have fats.
Giving Fibrates switches on enzymes to accelerate fat breakdown, as a secondary power source. The chunks of molecules broken off by the lipases are fatty acids. They stick on to carnitine, and get shuttled by a transporter into the mitochondria, where they can get used in place of the glucose downstream products that can't get in. Our chemistry changes the fat breakdown products to the same ones made from glucose, so the same cycle can run in the power plant, provided we get oxygen in.
If we give Carnitine, we can move them in faster.
If we give Fibrates, we can break down bodyfat to usable fuel faster.
Once we can replace the things from glucose, the protein breakdown can stop.
Next long fast, I'm doing this to stop muscle breakdown.
Actually, that might help people lose bodyfat under normal conditions, and possibly ameliorate exhaustion during exercise.
Pretty sure that just using the alpha ketoglutarate alone would do it. a-KG helps breakdown HIF-1a directly, as an enzyme co-factor, and would reverse the event sequence 2 ways.
Response capabilities are going to be greatly impacted by variants, spreading.
Here in STL, leaves are starting to come down, and the first signs of fall are showing, If the rain totals are any indication, it might be a wet one, followed by a nasty snowfall winter. Glad I don't have to commute. This may also impact variant spread, by limiting travel.
Oh, yeah. Speaking of water, it went out in my apartment complex yesterday. There is no aging infrastructure...
11 cases today in New Zealand. Down from 13 yesterday and 15 the day before. We are doing well, if you consider a largely asphyxiated economy “well”. Still 29 mystery cases with no link to known clusters. But more important than anything else, we need to get to no cases in the community at all.
I can easily agree with the above sentiment of needing to get to no cases at all. But my job is fine - searching for gold is a safe haven when the world is burning. Running out of stuff that needs shipping (everything in an island nation) mean that won’t stay fun for long I suspect.
How does mortality differ across countries? Examining the number of deaths per confirmed case and per 100,000 population. A global comparison.
coronavirus.jhu.edu
We're at 2.9% nationwide - a fairly poor showing at medical salvage. But deaths per capita isn't too bad at 98/100,000. That's evidence of lower speed transmission in the public. These are still pre-Delta numbers.
Once the transmission rate spikes up, the salvage number is going down hard. GVMC ran out of oxygen yesterday, started sending us(my hospital) (nonCovid) patients. Lack of sleep is dragging me a bit.
Covid is taking 5-10 per day to their graves, which can be likened to ~2000/day if we scaled up to USA size. Remember, that's mostly due to low level care, not high case count. Tried to get a specialist interested in using a metabolic correcting approach, but nobody here writes protocols, they just copypaste.
Despite the bad numbers, reopening is proceeding. Churches and bars will throw their doors wide by the end of the month. Working vs the carnage we expect is the slowing vaccination effort, but it is nowhere close to good enough vs Delta. We are going to pay through the nose for this. Starting my high riskers on fibrates meantime.
Back to 11 new cases/day here in NZ, after a brief lapse to 33. The COVID stomp-out is dragging out a long tail though there’s still a decline happening.
Meanwhile I got my first Pfizer shot. 6 weeks until the next one. Shoulder is sore, but that’s it.
Researchers in the United States, China, and the UK have called for immediate large-scale clinical trials of an antibiotic called rapamycin as a prophylactic and treatment approach to coronavirus disease 2019 (COVID-19) in older individuals.
www.news-medical.net
Rapamycin has anti immune system activity, inhibits protein synthesis, and has strong anti ageing properties. It has 3 possible modes of action in affecting severe Covid, but during active infection the suppression of protein synthesis could impact virus replication.
Low dose treatment in older lab mice has also been shown to improve later vaccine immunity for influenza. Even if it does zero for the acute disease, it might amplify the immunity gained from infection.
Trying to work out why fat metabolism doesn't work in severe Covid pneumonia. Why do we need to artificially help that along? Obviously, because it is broken!
Think I found a possible cause.
aging leads to reduced transcription of OCTN2 mRNA [87], the l-carnitine transporter, indicating that tissue distribution and homeostasis of l-carnitine is hampered with advanced age.
Gotta love a fuel supply gene that sounds like "Octane".
This impairment will reduce fatty acid energy supply to muscle, brain and heart mitochondria.
It explains increased fat storage, skeletal muscle atrophy, and decreased cardiac performance in older people, and might be one reason why the energy crisis in Covid pneumonia is so severe in them.
In every fat person, this gene is likely downregulated, slowing down fat breakdown. Hence, they got fat. Obesity is a leading Covid risk factor for death. Maybe it's not because of fatness, but a shortage of Carnitine transport.
If we can't move fatty acids out of the bloodstream and into tissues, we get cardiovascular disease worsening, fat globule collections inside cells such as fatty liver disease, and insulin resistance developing. In the brain, reduced neuronal energy intake will drive dementias.
Simply giving more Carnitine might not work effectively. Without the transport protein, it simply won't get to the sites of action. Epigenetic reactivation of the OCTN2 gene is required. There's a way or six to do that. The gene promoter is
PPAR-γ .
Prolonged hypertension is the leading cause of heart failure. Failing hearts show reduced peroxisome proliferator-activating receptor (PPAR) activity and enhanced nuclear factor κB (NF-κB) activity,
www.ahajournals.org
Increasing PPAR-γ (with grapes in this trial) would promote the OCTN2 gene.
Curcumin intake does it. Vigorous exercise does it. Troglitazone drugs work too. Our favorite compounds cyanidin and apigenin also work. Micardis will work too.
PPARγ has emerged as a master regulator of macrophage polarization and is the molecular target of the thiazolidinedione drugs. Here we show that apigenin binds and activates PPARγ by acting as a modulator. Activation of PPARγ by apigenin blocks p65 translocation into nuclei through inhibition of...
www.meta.org
This provides another possible pathway to explain why anthocyanins intake give better survival from Covid.
The Ministry of Health noted the cases are a non-national who recently travelled to Trinidad from Venezuela, an unvaccinated minor and an unvaccinated adult.
In the instances of both the unvaccinated minor and adult, the Ministry said epidemiological investigations into the source of transmission continue.
SARS-CoV-2 genomic surveillance in Uganda provides an opportunity to provide a focused description of the virus evolution in a small landlocked East African country. Here we show a recent shift in the local epidemic with a newly emerging lineage A.23 evolving into A.23.1 which is now dominating...
Over the weekend, in Germany a 20 year old cashier at a gas station got killed by an aimed Headshot by a man whom he refused to sell a sixpack of Beer because the shooter wore no ffp2 (=n95) or medical mask ( as many businesses in Germany still require to do do ) .
The guy went home, changed his clothes, did some other stuff . Came back almost 2hrs. later to shoot the cashier .
Guns are not really to own easy in Germany . Or well...it depends .
Over the weekend, in Germany a 20 year old cashier at a gas station got killed by an aimed Headshot by a man whom he refused to sell a sixpack of Beer because the shooter wore no ffp2 (=n95) or medical mask ( as many businesses in Germany still require to do do ) .
The guy went home, changed his clothes, did some other stuff . Came back almost 2hrs. later to shoot the cashier .
Dont know . He had a lot of time to think . At the least he will have a hard time claiming he "simply lost it" in front of court . From what I gathered from media, he illegally had a small collection of Firearms at home (I don't know details).
Public on social media is a lot about "Who is REa1lly t0 blam3 ???" and "Fight them (i.e. "the peole who would kill over a mask"), now !" .
Have not seen anyone xcept me asking yet "When did he start to illegally buy guns ? Where did he get them ? Are there others like him, do we know who they are, how many, where ? What do we have to do so this stays an outlier?" .
Germany may be on a really bad trajectory . We will know more by end this year I guess .
The stress of the ongoing crisis has affected humans in different ways. The ones with animus towards other humans, who value themselves above others, are emerging in every country. They cannot realign to a nonhuman threat at all.
The rest of us are exhausted.
It's horrifing sometimes to reflect on who might be walking along the street with you, what maladaptations they are working under.
Temperatures here have climbed. We will have to leave the island before the seas rise. Timeframe is the biggest question. They couldn't vaccinate and wear masks. So we will fail climate change, because of the same people.
It's incredible to think that there are people who think casual violence is an acceptable response to such simple issues like being denied service. Good thing they didn't have to put up with decades of prejudice like others have had to.
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