The RNA, technically, yes.
As far ss I can tell, it checked out manually.
If you buy a sliced loaf, the slices should all go stale at about the same rate. Come back to it a week later. All the slices are stale and cold except ONE. It is totally fresh and still steamy warm from the oven. As we watch it though, it goes colder and staler at a normal pace.
How would we explain that?
Easy. It has been swapped in, by somebody. It isn't a Magic slice. It ages like the rest.
The gene for the E protein stayed the exact same for "50 years." worth of evolutionary change? Then it started mutating? At 1 mutation per month, the present rate, we should see 50 x 12 = 600 point mutations.
that same freedom that now a few idiots proclaim (also happens in my country), and that can lead them and others along with them to death.
If many of the responsibilities fell only on those people and not on governments, now there would be more than half the world infected.
Who do you think designs and proposes laws, those "responsible" and "free" people?(at most you will write a name or an X on a piece of paper).
That certain governments or countries are not interested in regulating these aspects of life, does not mean that others do not,
but they should ,because it is their responsibility the health of their citizens too.
(See school canteens in those countries of the first world for example, without any type of sanitary control, do you think that in my country we are less free by control the health of a child? Seriously, you use the word freedom so much, that it loses all meaning.
I don't put a whole lot of stock in democratic power. In most democracies I'm aware of only a relatively narrow range of prevetted candidates can generally expect to get very far (though some are more dynamic than others), and many democratic processes fall well short of their ideals, leading to widespread disenfranchisement.
I'm not a virologist, microbiologist, or even particularly good at chemistry, but the loaf of bread analogy doesn't really work for me. Mutation and selection doesn't always work at a predictable pace, at least not at the individual gene level. Given the importance of this E protein and the limited number of possible arrangements for it, it does not seem unusual that it would be strongly conserved.
Even if it wasn't strongly conserved, there are undoubtedly other coronaviruses that had this particular gene, in other reservoirs, which could have infected the same host, and resulted in a novel, reassorted (which is known to be a main way in which coronaviruses evolve), virus with some previously known 'older' genes which then went on to infect millions and change at a vastly higher rate (more hosts, more copies of the virus, more opportunity for change) in the process of doing so.
Ultimately, I don't have the background or ability to make a convincing assessment for myself one way or the other, but I am fairly confident that if there was any real compelling evidence that SARS-CoV-2 had been artifically engineered, many credible sources would be making a big deal about that point by now. There is no threat from China, and no global conspiracy, that could keep hundreds of labs and thousands of researchers all silent.
Given the importance of this E protein and the limited number of possible arrangements for it, it does not seem unusual that it would be strongly conserved.
That is logical. Skepticism is highly encouraged.
(I am hardly even literate in this area. Appreciate the rational objections.)
If you are inclined to do so there is a bit of a counterargument. It is technical. There are pictures. Skip it if life is too short
Our laboratory has been using genetic methods to study the MHV E protein in the intact virus. In previous work we found that certain charged-to-alanine mutations constructed in the E gene resulted in defective virus growth and in thermolability. The assembled virions of one such mutant had striking defects—elongated and pinched shapes—that were seldom seen among wild-type virions (14). This phenotype was clearly consistent with the critical role for E protein in virion assembly indicated by the VLP studies. It was therefore surprising that we were later able to generate a viable, albeit extremely defective, MHV recombinant (ΔE) in which the E gene, as well as the accessory genes 4 and 5a, were entirely deleted (30). This confirmed that although the E protein is important for MHV assembly, it is not absolutely essential.
The E protein is not a critical element. There's no pressing reason for it to even be present to get a viable virus. It can totally take a lot of mutation and keep ticking. But it works better when it has the standard arrangement.
I know it looks like Greek Lego. Look over at the Right, you'll see the (E) section, in deep blue, showing near 100% conservation- except it isn't "near" - it is actually 100%.
The protein is a chain of amino acids.
Each amino acid is coded by a codon of 3 letters. eg: AGG GGG GUC along the RNA
It's completely possible to get the same amino acid with errors in those codons, at one point of 3. A silent mutation. The gene doesn't even have those silent errors. Which would not change the protein, and there are hundreds or thousands of possible versions that would do that. It is instead a carbon copy of the bat gene.
QED, it isn't trying to conserve the protein from error. There simply WERE no errors.
Except in the wild SARS Cov 2 virus- that suddenly gets 4 of them in 4 months, and no real effect on the performance, as we would expect from a non critical element.
So-
non critical protein
No reason to conserve it, mutations would be fine
Even errors that would conserve it are inexplicably absent
Errors immediately start appearing once it moves out of Wuhan, and it's still working.
Researchers led by Shan-Lu Liu at the Ohio State University say there is “no credible evidence” of genetic engineering (Emerging Microbes & Infections, doi.org/dpvw). The virus’s genome has been sequenced, and if it had been altered, we would expect to see signs of inserted gene sequences. But we now know the points that differ from bat viruses are scattered in a fairly random way, just as they would be if the new virus had evolved naturally.
I am saying that statement in bold is false, according to direct reading of the code ( manually is subject to human error) . There is a big chunk of bioidentical code with no evidence of random mutation of any kind, coding for bioidentical envelope protein. That is a glaring sign of an inserted gene. Do not know why they did not see it, but my bet is nobody looks at envelopes- or I missed errors that invalidate the position.
Going to be away for a while. Good luck to all. Enjoyed the company.
But do we really have the freedom to think freely? We take an action because we think it is our decision, our free will, but we are so conditioned that we don’t even realise it isn’t our choice.
Isn’t this partly what this thread has discussed? The illusion of our current lifestyle? What is normal?
It appears to be a key part of being human though, to be a sheep
And that is exactly what happens in the United States ... do you really think that a country of only 500 years old and one of the last to abolish slavery is going to teach others about freedoms? look around you and tell me how free you think you are, involved in wars with half the world ...I think that is the only freedom you can enjoy, but that will change one day,is already happening
But do we really have the freedom to think freely? We take an action because we think it is our decision, our free will, but we are so conditioned that we don’t even realise it isn’t our choice.
Isn’t this partly what this thread has discussed? The illusion of our current lifestyle? What is normal?
It appears to be a key part of being human though, to be a sheep
Personally I think we have far more freedom than we ever bother to utilise. This also includes the freedom to do stupid stuff and the freedom to be manipulated, of course.
Unfortunately we haven't evolved that much since we climbed down from the trees. Intelligence and logic aren't what our brains are good at. Our brains are good at pattern recognition.
This means that we need to use complex formal systems like mathematics, to find logical answers. Patterns (and false patterns) on the other hand are recognised instinctively, faster than our conscious thoughts. This means that we in most cases, will chose what we are familiar with over what is sensible.
This weakens is what the marketing industry utilises to manipulate us, commercially and politically. They take the time to use complex formal systems, to target our greatest weakness.
Similar manipulation also happens in a less calculated way in social groups, like a family, a work environment or a group of friends. These social enforcement patterns evolve naturally, simply because they are effective.
Non of this means that we aren't free. It just means that we are horribly poor at understanding how free we are.
Must say I am confused about why UK is planning to relax our 'lockdown'. The new cases look like:
so, to my non-expert eye it seems we're running with more or less constant new cases for the last month (i.e. throughout April). The government seem to be saying this is due to increased testing (so they're saying that we're finding more cases by testing more people). But that doesn't seem to fit with the number of tests:
So the number of tests increased at the start of May, not the start of April - if the number of tests was material surely we'd have seen a jump in cases at the start of May? But I could just be getting confused, as the number of deaths is coming down ...
In comparison if we look at other countries relaxing restrictions we see that their 'new cases' rate has dropped - and I doubt that's because they're doing less tests - Spain for example:
And that is exactly what happens in the United States ... do you really think that a country of only 500 years old and one of the last to abolish slavery is going to teach others about freedoms? look around you and tell me how free you think you are, involved in wars with half the world ...I think that is the only freedom you can enjoy, but that will change one day,is already happening
you’re correct in some of your points, the endless wars are not something “we the people” want, that is actually one of the reasons Trump won the election, no more wars.
Only a few people supported slavery and it took a Abraham Lincoln to end it.
a free person can own land, carry a knife, gun, rifle without being harassed by the law, yes there are issues with that but that’s the prize I and many others a willing to pay. A free person can also work where he or she want, work when they want whiteout being harassed by the law, right now we are challenged by the virus and draconian lawmakers, but in the end we will win, not them. The ground is burning and our forces are multiplying day by day, so there you go
I agree, although some vote for the least worst, because of lack of choice and some abstain from voting which also promotes the accession to power of people who are not wanted
There are many governments that have a fundamentally partisan and real electoral base, very inferior to the totality of the inhabitants.
Well there is the rub. Its all very well pointing a finger at the people who put a government in power but lets face it, what real choice do we have?
I don't really differentiate from any of the options presented during elections
you’re correct in some of your points, the endless wars are not something “we the people” want, that is actually one of the reasons Trump won the election, no more wars.
Only a few people supported slavery and it took a Abraham Lincoln to end it.
a free person can own land, carry a knife, gun, rifle without being harassed by the law, yes there are issues with that but that’s the prize I and many others a willing to pay. A free person can also work where he or she want, work when they want whiteout being harassed by the law, right now we are challenged by the virus and draconian lawmakers, but in the end we will win, not them. The ground is burning and our forces are multiplying day by day, so there you go
The prinsipal of freedom is that it ends where the next persons freedom starts. You can not work where or when you want, if it puts others in danger.
I can for example not build and run an open air chemical production facility next to the local primary school, even if I own the land. We all accept this, as we are used to it.
The situation now is that things we are used to doing, is suddenly dangerous to others. The boarder where our freedom ends has moved. As no one knows exactly how much, there will be disagreement.
Corona laws are not an attack on the principal of freedom. They are only a boarder adjustment. They may not be perfect. They may even in some cases be way of. That is however more of an academical debate than a prinsipal one.
you’re correct in some of your points, the endless wars are not something “we the people” want, that is actually one of the reasons Trump won the election, no more wars.
Only a few people supported slavery and it took a Abraham Lincoln to end it.
a free person can own land, carry a knife, gun, rifle without being harassed by the law, yes there are issues with that but that’s the prize I and many others a willing to pay. A free person can also work where he or she want, work when they want whiteout being harassed by the law, right now we are challenged by the virus and draconian lawmakers, but in the end we will win, not them. The ground is burning and our forces are multiplying day by day, so there you go
And what good is that if your government monitors / controls you 24 hours?
It is curious that the use of these "weapons" in the name of freedom, only takes you to 2 destinations that have nothing to do with it, prison or death.
Since 50 percent of the population is obese,I don't see very prepared forces if a war were brought to your land.
The prinsipal of freedom is that it ends where the next persons freedom starts. You can not work where or when you want, if it puts others in danger.
I can for example not build and run an open air chemical production facility next to the local primary school, even if I own the land. We all accept this, as we are used to it.
The situation now is that things we are used to doing, is suddenly dangerous to others. The boarder where our freedom ends has moved. As no one knows exactly how much, there will be disagreement.
Corona laws are not an attack on the principal of freedom. They are only a boarder adjustment. They may not be perfect. They may even in some cases be way of. That is however more of an academical debate than a prinsipal one.
That’s true, we agree on that one, however if you have a hairdresser, who opens their studio, you are free to enter or stay out, no one is forcing you to use that service and he or she is not in anyway a danger to you or anyone else.
And what good is that if your government monitors / controls you 24 hours?
It is curious that the use of these "weapons" in the name of freedom, only takes you to 2 destinations that have nothing to do with it, prison or death.
Since 50 percent of the population is obese,I don't see very prepared forces if a war were brought to your land.
fat people are everywhere, there are also a lot of people who are normal, and people don’t need to do any fighting, if they despise the authorities enough, they won’t corporate and that alone is wining.
300.000.000 guns, if just 300.000 is capable you lose, no matter what you bring. Afghanistan, Korea, Vietnam is a perfect example of that, and they didn’t even had that.
fat people are everywhere, there are also a lot of people who are normal, and people don’t need to do any fighting, if they despise the authorities enough, they won’t corporate and that alone is wining.
300.000.000 guns, if just 300.000 is capable you lose, no matter what you bring. Afghanistan, Korea, Vietnam is a perfect example of that, and they didn’t even had that.
I don't know if the Americans know or you will have forgotten, but before America and weapons were one thing, the world already carried weapons freely thousands of years ago, which led to certain highly inadvisable or unhealthy historical situations to govern.
The US had to review a bit of history before allowing the use of weapons, Rome or Japan were good examples.
I mean, if Lincoln or Kennedy had read Julius Caesar's story, they could have prevented his death. (There are hundreds of examples)
That’s true, we agree on that one, however if you have a hairdresser, who opens their studio, you are free to enter or stay out, no one is forcing you to use that service and he or she is not in anyway a danger to you or anyone else.
In the early stages when details virus spreading are unknown, it's smart to close them down. It's not as essential service. As long as you remember to pay the hairdresser, there is no harm in doing so.
As soon as it's known how safely conduct the service, it should of course opened again.
Hairdressers i Norway were closed for 5 weeks. They are now open, with a set of rules that must be followed. It worked fine.