By "responding" I presume that you mean that it hears and recognises your voice, logs that recognition on its main window, but the programmed actions do not have effect.
Thoughts...
1) If running Elite as administrator, you would also need to run VA as administrator - NOTE I do not advocate running EITHER as administrator - the opposite infact - both the programs should be run as an unprivileged user unless you have some other overriding reason.
2) The Elite Dangerous client window is not the active window at the time.
I generally target all of my VA actions at the "Elite - Dangerous (Client)" window (it's a setting in the "Options" button at the top of the profile window) - the only exceptions being my command to launch ED (targeted with the command at "Program Manager"), a command that I call "comms check" (which just speaks "Communications O K", as confidence VA is hearing me) and (in future) commands to launch other VA profiles.
3) Your key bindings don't match the VA macros any more (reprogram the bindings, and use advice elsewher in this forum to save your custom bindings under a different name so they do not get reset by updates, - also you can keep backups of that bindings file).