In my experience, having clocked a few hundred hours on E: D in VR, it's great provided you're not actually doing stuff.
VR in E: D is its own game... and the other stuff that surrounds it isn't really that important when you get the headset on. You just gawk at the stations, your ship, other ships, planets, etc. It's truly glorious at times.
But for me at least, on a DK2 and now a CV1, the text is still too hard to read comfortably... so, grinding missions, or resource collection, or trading, or whatever... is better in 2D for long periods IMO.