I tested many weapons on a Cobra in Beta 2/3. Especially in the conflict zones, all those "kill 9 ships" missions we used to have, combined with the "kill civilians" missions, meant spending a long time fighting between reloads.
2 Medium Gimbaled Pulse Lasers
2 Small Gimbaled Multicannons
My reasoning is that on those long missions, I'd sometimes run out of ammo, so I found having the 2 heavy pulse lasers better since they are still very effective when my guns run dry. If you rely on the heavy multis, and run out of ammo, you're stuck with wimpy class 1 lasers which are just not enough.
2 Medium Gimbaled Pulse Lasers
2 Small Gimbaled Multicannons
My reasoning is that on those long missions, I'd sometimes run out of ammo, so I found having the 2 heavy pulse lasers better since they are still very effective when my guns run dry. If you rely on the heavy multis, and run out of ammo, you're stuck with wimpy class 1 lasers which are just not enough.