I imagine it would. If someone in real life is used to seeing through one eye, then it would be the same in VR (imo). Where there is no depth perspective per se, but head movement would give that, as closer objects move more than far ones as in parallax (I think).It's it just a stereo offset image into each eye?
There was a follow in another thread who said it worked for him and he only has one eye.
Maggie_Oz, I think it was you some posts back that mentioned this being their condition. If so (I know we have different opinions about Odyssey and VR), and you'd like to adopt VR one day but saw this as a barrier, it may e worth investigating. The way you perceive the world naturally is that way, so it would be something you have adapted to anyway. Hell, you could have just the one screen and double the resolution without a performance hit on your rig!