I've found that if you have Nvidia card, it's much better to use DSR (Dynamic Super Resolution) setting than Supersampling. It doesn't have as severe impact on performance as ingame supersampling.
The performance impact is essentially identical at the same internal resolution.
However, the game lists a multiplier of the linear dimensions, while DSR resolutions show the multiplier of total pixel area...i.e. the 4.00x DSR resolution is the same resolution as 2.0x in-game supersampling.
I run this ontop of ingame settings.
Its for Nvidia cards from the control panel :-
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I've had 3 PCs all with Nvidia cards and the control panel has never worked on any of them
It never overrides
There are no MSAA settings to enhance and alpha-to-coverage isn't used for transparency AA either.
It can't be overridden either. The game doesn't support MSAA at all. Very few games with differed renderers do.
These options are mostly for DX9 and prior titles.