Question about sub-targeting modules in combat

Can anyone help clarify a few things for me?

* Is targeting your opponent's power plant still the way to go? Or does it depend on type of ship or whether PvP or PvE? Is there any general guidance?

* Is there any disadvantage in targeting specific modules? If I miss and still hit the ship presumably it does as much damage as if I wasn't targeting a module?
 
Targeting Power Plant is still effective, but lately, for PvE I've been targeting the FSD to prevent the target from jumping out so I can get the kill.
 
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