I have the X52 Pro and got the same issue last night right in the middle of a freaking fight, it ended up killing me.
Now, I'm not sure if this is an issue with the game or hardware related. I don't think (and I hope) it's not the latter so I'm wondering if any other user can confirm if his setup has the same problems or not.
Basically, seemingly at a random point in the game, all lights on my joystick start to flicker and it becomes unresponsive for a couple of seconds. It's random and I cannot pinpoint the cause.
The reason I'm inclined to think that it's an issue with the game is because it ALWAYS happens while I'm browsing station menus or the galaxy map, and randomly everywhere else.
Is there an X52 pro user who can verify it for me?
thank you