Not in my recent experience on Obamumbo, I did a bunch of passenger runs and there was almost always a Scythe hyperdiction on the first jump, but nothing after that.
I haven't done proper pod runs recently, but played with an anti-Scythe Krait build a couple of times (baited with some evac mission pods), both times I had to jump back and forth between Obamumbo and a nearby system twice before a Scythe took an interest. Not exactly a huge sample set though.
Okay, I just gave it a try with my hot zone Python that used to be fine before Scythes were introduced. I went to a damaged outpost and was
immediately attacked, lost shields before I even docked. So I repped and took all the passenger missions available, which didn't even fill my entire capacity - just about 110 out of 130 seats.
As I took off, I was again immediately under fire, lost shields, took hull damage, and did not manage to ECM the FSD-reboot missiles. Also couldn't prevent their limpets from docking. The reboot took FOREVER and when I finally jumped I was down to something like 55% hull.
In the first jump I was hyperdicted, and again did not manage to ECM the reboot missiles. But I managed to evade the enemy fire a bit better, still now when I finally high waked I was down to 36% hull. Passengers sure complained a lot!
At least the rest of the journey (3 jumps total to the rescue ship) was smooth sailing. I lost a total of 12 pax, but the survivors were grateful.
Still, I'm not doing this again unless I manage to improve my ship.
Turns out I didn't need heat sinks, SFN or CSL, so I might replace some or all of those with shield boosters, only keeping the ECM (which I apparently need to practice more with).
Also maybe I should replace the heavy duty Lightweight hull with a lightweight Military one. And maybe a bigger Prismatic shield, since there weren't even enough passengers to fill all the cabins I have. Downside is this all reduces my speed, which is already below 500 due to all those heavy cabins.
And obviously I should plug in a pre-engineered FSD. That's okay, I have one spare in another ship that doesn't need it.
Many problems could be solved by using my Clipper instead -- but that one can't dock at outposts, of course.