Yep.
I've actually never liked flying a Python in Open for that reason; if you come across a hostile player, there are a wide variety of situations you're at an inherent agility, speed, or firepower disadvantage. The possibility's always there you can be put in a situation that you just don't have the resources to fight your way out of, or even easily escape from. It's not that the Python's a bad ship or anything; it's just not a ship that can dictate the terms of a PVP encounter against the most commonly used ships and builds. I do, however, love using my Python as a mining vessel. But as a general-purpose Open runabout, I feel infinitely more secure in a Krait.
[EDIT] Just thought I'd add this picture. Thought it turned out nice.
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