General / Off-Topic The safest place
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Qanon have now gone even more antivax recently due to all their past prophecies failing and some MacAfee conspiracies apparently.
www.ozy.com
QAnon? Far From Gone
It’s the conspiracy theory that roiled the 2020 U.S. presidential election, inspiring claims of stolen ballots, anti-mask rallies and the infamous Jan. 6 insurrection at the U.S. Capitol. Yesterday, QAnon exploded back on the scene: Minutes after reports emerged that cybersecurity magnate John...
www.ozy.com
There are 1,143 drug trials now running in North America. For Covid.
(All on the unvaccinated, who didn't want to be guinea pigs.)
(All on the unvaccinated, who didn't want to be guinea pigs.)
Outbreak in Israel, Delta variant, infecting "fully vaccinated people", forcing another round of defensive measures.
www.hindustantimes.com
We are going to require third doses to get this under control, and since immunity from just prior infection is weaker than full 2 dose vaccination, and may wane faster over time, it's no longer accurate to hold that not vaccinating the previously infected is OK.
The new risk of infection is too great to rely on that.
AFAIK the protection levels go something like
1 MMR = previous infection within 6 months
2 One Dose O-AZ or mRNA vaccines
The protection between those above is not too dissimilar. Subject to correction as data comes out.
3 Two Doses O-AZ or mRNA vaccines
Currently termed "fully vaccinated", inadequate to halt Delta,
4 Two Doses of Different vaccines
Shown to be stronger than just one type, no data vs Delta.
5 Three Doses of same vaccine, either type
Reported to be able to stop "any variant", but data unpublished, cannot compare to 4 above, may be equal or lesser.
6 theoretically, Three doses of Different vaccines
About 50% infected adults in Covid-19 Delta variant outbreak in Israel fully vaccinated: Report
“The entrance of the Delta variant has changed the transmission dynamics,” said Prof Ran Balicer, who leads an expert advisory panel on Covid-19 for the government.
We are going to require third doses to get this under control, and since immunity from just prior infection is weaker than full 2 dose vaccination, and may wane faster over time, it's no longer accurate to hold that not vaccinating the previously infected is OK.
The new risk of infection is too great to rely on that.
AFAIK the protection levels go something like
1 MMR = previous infection within 6 months
2 One Dose O-AZ or mRNA vaccines
The protection between those above is not too dissimilar. Subject to correction as data comes out.
3 Two Doses O-AZ or mRNA vaccines
Currently termed "fully vaccinated", inadequate to halt Delta,
4 Two Doses of Different vaccines
Shown to be stronger than just one type, no data vs Delta.
5 Three Doses of same vaccine, either type
Reported to be able to stop "any variant", but data unpublished, cannot compare to 4 above, may be equal or lesser.
6 theoretically, Three doses of Different vaccines
As long as too many countries - especially many of those who have rather good supply of vaccines - keep on dialling down NPIs with the reason of "Once we'll all be vaccined, it'll all be good !" -> we are xactly one Variant away from almost 100% "back to square one. As Dr. Tedros said : "It is rather simple actually . More transmission, more mutations ."Outbreak in Israel, Delta variant, infecting "fully vaccinated people", forcing another round of defensive measures.
About 50% infected adults in Covid-19 Delta variant outbreak in Israel fully vaccinated: Report
“The entrance of the Delta variant has changed the transmission dynamics,” said Prof Ran Balicer, who leads an expert advisory panel on Covid-19 for the government.
We are going to require third doses to get this under control, and since immunity from just prior infection is weaker than full 2 dose vaccination, and may wane faster over time, it's no longer accurate to hold that not vaccinating the previously infected is OK.
The new risk of infection is too great to rely on that.
AFAIK the protection levels go something like
1 MMR = previous infection within 6 months
2 One Dose O-AZ or mRNA vaccines
The protection between those above is not too dissimilar. Subject to correction as data comes out.
3 Two Doses O-AZ or mRNA vaccines
Currently termed "fully vaccinated", inadequate to halt Delta,
4 Two Doses of Different vaccines
Shown to be stronger than just one type, no data vs Delta.
5 Three Doses of same vaccine, either type
Reported to be able to stop "any variant", but data unpublished, cannot compare to 4 above, may be equal or lesser.
6 theoretically, Three doses of Different vaccines
One would think Delta is making this clear enough by now . Sadly, Germany for instance is doing exactly what I wrote above - doing away with NPIs ( even though we have rather medicore vaccine coverage...) - all the while we are watching UK, Israel to sadly start suffering again due to the capabilites of that variant .
One thing striking me is that is starts looking like vaccines are not as effective against transmission as has been believed . Not sure though, maybe most of these new cases are amongst unvaccinated . In any case -> more people become susceptible to reinfection as time goes on .
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Realistically 100% vaccination against all variants is impossible due to evolution. We are going to have to manage this like the flu. As time goes on there will be more general immunity.
Wearing masks and blocking travel etc can’t restart every time there is an outbreak. It’s people dying and healthcare systems being swamped that matter in countries with sufficient vaccination.
I can’t help but think people have become a bit too wrapped in cotton wool with all the responses to covid. It’s heavily reducing transmission, dramatically reducing hospital admissions and using the same sort of scale has almost stopped deaths. The U.K. is testing at a ridiculously higher level than when all this started. Zero covid is not something I’d support because it’s unrealistic, impossible and not worth the effort when vaccines stop people dying.
Probably true. Registration, testing and deployment processes are too slow for the globe to react. But the technology to recode and make new RNA vaccines is in place.
UEFA Wembley stadium, June 29th, Germany vs England. Seats 90,000. German ticket allocation is 7000, approx.
UK is now 95% Delta by prevalence. Vaccinated people will travel. Delta will break through.
Let's call it 3 because of the resistance with a vaccinated population in Germany. If 1/10 of the travelers catch it, 700 cases. This is a guess. 4 days to incubate.
Gen 1: 700, 3rd July ( approx current daily rate of infection, so we should see Germany's numbers double overnight, with 14 days to infect the next generation)
Gen 2: 2100, 17th July
Gen 3: 6300 <---- 31st July By this time practically nobody will be having any other kind of Covid.
Looking at trouble by August, but in the height of summer, the rates may decrease significantly. Let's hope so. Too many confounding factors to predict.
Alt calculation, doubling time was 11 days in the UK for Delta. ( My crude math suggests this is in the same ballpark? A bit slower than above, but the UK is ahead in vaccination.)
Gen 1: 700, 3rd July
Doubled: 1400, 14th July
X4: 2800, 25th July
X8: 5600, 5th August
I'm all for football restarting, but not Covid restarting. Maybe this game should be left without travel?
To assume this Virus will turn out to be manageable like "the "flu" is optimistic . It is a hope . There still is ample potential for SARS-CoV-2 to become way worse than what we have seen so far . Delta very impressively gives a glimpse of what is still possible . I mean, did you think Israel is out of the rough ? And Uk, too ?
Besides, we ( humans ) occasionally botch up our "managing of the flu" royally . Think season 2017/2018, but with a Virus with IFR about 50x 'flu IFR . IF it stays that way .
And keep in mind what it is able to do to infected people who appear to have dealt with it . Have you seen the numbers on readmissions of people having been discharged from hospital, declared "healthy" ? How many people die 3, 6 months after appearing as if they have cleared intial infection, just by what that infection has done to them ?
We are 1 Variant away from back to square 1. More transmission, more mutation .
I for one do NOT want this to go on spreading as it is spreading now . .
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Any time you took any pharmaceutical drug, got any vaccine, you effectively have been a guinea pig .
Capacity will apparently be limited to 60k but the point still stands.
Making it worse has been the EUFA insistence of relaxed restrictions for officials and VIPs.
COVID-19: Government changes rules to allow visiting officials and VIP fans to attend latter stages of Euro 2020 at Wembley
Minister John Whittingdale says there will be "some people coming in" for games but they will be under "strict restrictions".
It looks like proof of vaccination or negative PCR test is a condition of entry but even so - seems to be a bit too much with this new variant.
It looks like here in the UK the hope is the vaccine will restrict spread and limit severe illness enough to make it workable.
Whilst hoping mutation won't get much worse. I mean it's more infectious but presumably that must reach a limit at some point? Transmission still has to obey the laws of physics and if it gets more deadly that works against it anyway.
It's all a bit wait and see.
Here is the thing, I rarely take any drugs at all, and when I do, I do it freely.
I'm not scared to be around sick people, and I'm not going to chip away freedom for anyone because I'm scared.
Now you can agree or disagree, that's up to you.
It's a bit worrying that Pfizer is failing regarding preventing the spread but i have never had much faith it would do that.
However, all our most vulnerable had Pfizer around the same time as Israel so i guess we will see it in the care homes again.
I can't see them taking precautions until it's a problem either...and probably too late.
So, once more intn the breach, it seems.
If it fails to protect, it will be bad.
However, all our most vulnerable had Pfizer around the same time as Israel so i guess we will see it in the care homes again.
I can't see them taking precautions until it's a problem either...and probably too late.
So, once more intn the breach, it seems.
If it fails to protect, it will be bad.
I also rarely take any drugs. I have only had one course of antibiotics in my 47 years. Rarely take paracetamol, Ibuprofen etc unless I really need it. That is not a freedom position for myself, it's just me being obstinate.
I'm not scared of being around sick people either but I wear a mask in shops because it is safer for everyone involved, I certainly wouldn't want to be carrying a virus that can kill other people or make them extremely ill regardless of how it might or might not affect me.
The majority of people are not taking the jab because they are scared, they are taking it for society as a whole and especially for those who have compromised immune systems etc. This allows them to get the majority of their actual freedom back sooner rather than later.
Maybe I am wrong here but what I see with anti-vaccinations is that it is a ME issue while for everyone else it is an US issue
There's a human gene that mutated long ago, designated CMAH.
CMAH coded for a protein enzyme needed to make a sialic acid substance found on cell surfaces. Humans lost the ability to make it. Other animals still make it. It's now a foreign substance, acquired by eating meat.
There's a hypothesis that coronaviruses can use that as a receptor or a doorway into cells.
Ok, so if that is true, then vegetarians should get less severe disease. Our mutation is a survival advantage, compared to other critters, but not if we eat them.
Edit: that mutation would be an advantage by protecting vs pathogens in any species that is not carnivorous, and since NO living humans have the gene working, the ones without the mutation died out at some point. Maybe becsuse of a prehistoric pandemic?
www.independent.co.uk
Hypothesis confirmed, it seems?
Maybe. Maybe something else like more phytochemicals might be the cause. But a positive dietary adjustment (eating more vegetables) is still a good idea. That sialic acid is linked to autoimmunity problems, it's found in our arterial plaque, where inflammation causes clots, and it has been implicated in cancer.
www.pnas.org
(Eat safe meat. Other people. Nom nom nom.)
CMAH coded for a protein enzyme needed to make a sialic acid substance found on cell surfaces. Humans lost the ability to make it. Other animals still make it. It's now a foreign substance, acquired by eating meat.
There's a hypothesis that coronaviruses can use that as a receptor or a doorway into cells.
Ok, so if that is true, then vegetarians should get less severe disease. Our mutation is a survival advantage, compared to other critters, but not if we eat them.
Edit: that mutation would be an advantage by protecting vs pathogens in any species that is not carnivorous, and since NO living humans have the gene working, the ones without the mutation died out at some point. Maybe becsuse of a prehistoric pandemic?
Are people following a plant-based diet less likely to get severe covid? Study says yes
Research finds relationship between diet and vulnerability to coronavirus
www.independent.co.uk
Hypothesis confirmed, it seems?
Maybe. Maybe something else like more phytochemicals might be the cause. But a positive dietary adjustment (eating more vegetables) is still a good idea. That sialic acid is linked to autoimmunity problems, it's found in our arterial plaque, where inflammation causes clots, and it has been implicated in cancer.
A red meat-derived glycan promotes inflammation and cancer progression
We present an unusual mechanism for the well-known association between red meat consumption and carcinoma risk involving the nonhuman sialic acid N -glycolylneuraminic acid (Neu5Gc). We first evaluate the Neu5Gc content of various foods to show that red meats are particularly rich in orally...
www.pnas.org
(Eat safe meat. Other people. Nom nom nom.)
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Definitely.
It's interesting to observe in antivaxxers the lack of aversion to the ones potentially infected, as predicted in this paper.
Damage to the ventromedial prefrontal cortex reduces interpersonal disgust - PMC
Disgust for contaminating objects (core disgust), immoral behaviors (moral disgust) and unsavory others (interpersonal disgust), have been assumed to be closely related. It is not clear, however, whether different forms of disgust are mediated by ...
www.ncbi.nlm.nih.gov
The same defect that stops brains from false tagging lies, stops brains from tagging other people with social disgust. Hence opposition to vaccine passports, because those are percieved as unfair by the tag-blind.
This isn't simple stupidity. It's a specific disability.
It's tailor made to drive pandemics. A real behavioural hazard today.
There is that bug that makes rodents suicidal. It's also prevalent in humans. More study required.
The Game Master was angered by the closure of my grocery!
Great Fiery Death From The Sky!
Or, in other words, yet another thunderstorm weekend and Monday. Normal STL weather.
Got beaten at Medici and King Of Tokyo at game night tonight. Truly uplifting.
On topic: the number of persons wearing masks is diminishing rapidly. Many are weary of restrictions. Outdoors, few wear them. I'm glad I had my shots, but worry about variants. Many want to put everything behind them, and resume a "normality" that probably won't exist again.
Also somewhat on topic: The housing bubble is still in full sway. At my friends house, there are multiple properties being demolished, and being rebuilt. At fantastic cost. The one next to M. De Poisson's has so many gables on it, we call it 1313 Mockingbird Lane.
Great Fiery Death From The Sky!
Or, in other words, yet another thunderstorm weekend and Monday. Normal STL weather.
Got beaten at Medici and King Of Tokyo at game night tonight. Truly uplifting.
On topic: the number of persons wearing masks is diminishing rapidly. Many are weary of restrictions. Outdoors, few wear them. I'm glad I had my shots, but worry about variants. Many want to put everything behind them, and resume a "normality" that probably won't exist again.
Also somewhat on topic: The housing bubble is still in full sway. At my friends house, there are multiple properties being demolished, and being rebuilt. At fantastic cost. The one next to M. De Poisson's has so many gables on it, we call it 1313 Mockingbird Lane.
Interestingly, it's recently been determined that white blood cells use a Spiderman like method to tackle Covid 19.
They unravel their DNA, break down their nucleus, and then spit it out as a tangled web. The acronym for this is Neutrophil Extracellular Traps or NETS.
While this is out since 2017, nobody has positively shown it working in Covid before.
There's a drawback to using DNA as a structural net - it breaks down into chunks that can drive autoimmunity. Anti-Nuclear-Antibody most likely forms this way, a marker for severe diseases like lupus and Rheumatoid disease. This is not a process anybody would want running internally any more than necessary to stay alive.
Edit:
Actual picture of a stained slide of a NET
As you can predict now, the higher the elevation of your WBCs in Covid, the worse the disease is going to be. Because- more NETS.
They unravel their DNA, break down their nucleus, and then spit it out as a tangled web. The acronym for this is Neutrophil Extracellular Traps or NETS.
While this is out since 2017, nobody has positively shown it working in Covid before.
There's a drawback to using DNA as a structural net - it breaks down into chunks that can drive autoimmunity. Anti-Nuclear-Antibody most likely forms this way, a marker for severe diseases like lupus and Rheumatoid disease. This is not a process anybody would want running internally any more than necessary to stay alive.
Edit:
Actual picture of a stained slide of a NET
As you can predict now, the higher the elevation of your WBCs in Covid, the worse the disease is going to be. Because- more NETS.
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First public indication that coronavirus may be present in North Korea.
Kim Jong Un had vanished from public for 4 weeks. Reappeared with a much thinner appearance. Dictators often conflate the country with themselves.
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