I run tripleheaded religiously - couldn't live without it (and TrackIR). I've been considering UltraWide, but I'd want to run 3 of them and my 980 won't do it.
For the OP - it's simples. Not sure which ports you have on your Titan, but provided you have the native ports on the monitors (I had to do one DP <> DVI), it'll be fine. Although don't mix HDMI with other types (DP/HDMI) as that can cause issues.
Then run the Nvidia tool, enable surround, and off you go. You'll need to adjust the FOV up a bit most likely.
One point to note - the Galaxy Map implementation on tripleheaded is a pain - the left hand menu window is positioned under the bezel. If you're going to use bezel management, that can cause a problem as you can't see to type in the search box or see the data in that window, so I usually run with bezel management off when playing ED - it's no biggy as most of the cockpits don't have structure crossing the bezel same as you'd get in a flight sim. But it is worth noting. I've raised bug reports for the map view previously, but so far nothing from FD as regards getting it fixed
The Nvidia surround desktop management is also pretty nice, you can get your Task bar on just the central one, and windows maximise to individual monitors rather than the full span - the exception being video which goes "full screen". If you need more control, check out Display Fusion (3rd party app). I used DF to get around some limitations of ATI/AMD's eyefinity before I went to Nvidia, but Nvidia has been far easier to configure/use.