Then came the Engineers. The Engineers place a goal in front of you. You may decide whether you will actively work towards it or just get on with whatever you were doing before, stumbling your way around the galaxy in the 'scientifically proven 100% correct' way of playing the game.
I believe, if I understand him correctly, Starender is actually referring to the fact that if you do indeed decide that you might like to work towards a goal in the 'heretical, unscientific wrong' way of playing the game then you might find a weird feeling come over you as you spin the wheel of fortune at the Engineer and realise that, perhaps, some work you invested in, did not quite work out the way you had hoped. This has indeed been my experience, keeping in mind that I have been part of this elect group of people that play the game in the 'scientifically proven 100% correct' way.
Setting goals in games and working towards them intentionally and deliberately, expecting to be rewarded in a consistent fashion, is neither sinful or heretical, especially in a game like this.