With the new and improved AX multi-cannons and missile-racks there are plenty of highly-practical builds that don't involve Guardian tech, so it'd be silly to miss out on this gameplay on that basis alone. Indeed, it's only recently that players in Titan space have started re-using Guardian tech at all. The first few Titans were taken down completely without it.
I'd like to say that it will only apply in Titan Space, not the whole system... however as this is a somewhat unusual event it's hard to predict what the exact rules will be if/when Cocijo arrives in Sol. Also the Glaive Hunters and Orthurus Interceptors can melt Guardian tech, and we can't say how prominent they might be in whatever is going to occur.
(I'm wondering if, without orbiting an Ammonia World, the Titan's corrosive effects might even be entirely absent.)
I would suggest starting with a build that uses Human tech only, but then swap in whatever Guardian tech you like after that, so it's only a quick pitstop to change back again if it turns out the anti-Guardian field is going to cause issues. My main AX Combat ship uses un-protected Guardian weapons, but I always carry AX Multi-Cannons too, so that I'm not defenceless if some Glaive Hunters show up and melt my primaries.