Something that bugs me about the new clue, is that it isn't. A ship called the heart and soul broadcasts a location near the heart and soul and cryptic phrase of constellations that surround again the heart and soul. Saying heart and soul over and over again could anything be less nebulous? Less of a clue than being treated like puppies that peed on the carpet and having our noses rubbed init?
I would say perhaps instead to treat it like an onion? The transmission has layers of encryption and obfuscation. Each one is peeled off in turn to reveal another step in the process.
So:
1) Decodes to EAFOTS. A pretty easy one indicating a starting destination, so go from Tionisla to Eafots Region - and the H&S specifically, given the Cobra's name.
2) Decodes to some plain-text gibberish ... that includes references to four classic constellations. So use that clue to go from H&S to the next point on the route. I don't believe this bit is anywhere near as simple as the other - especially not since seeing that arrow. What about moving parallel to the arrow
from the H&S region? (up offplane, clockwise) Translate the vector the arrow gives onto your present location.
3) Decodes to ??? - but something only particularly usable from the destination of clue 2, I expect, and which might not be revealed until some people at least have got there.
I had a quick look in the galmap as to what was offplane and clockwise and didn't see anything obvious, but the galmap isn't great for that sort of work - maybe it's more obvious if you're sat at H&S and heading right for it? Sorry I'm too far out to help this time.
(Note that people were talking about asterisms from H&S, and the constellations mentioned in the clue, before the clue came out - this was in theory solvable earlier, if the arrow is real)
Also remember: thinking about the chronology Drew must have planned out the rough location before the real ED galaxy was available - so "things which are reasonably likely to be in the same place in Space Engine" are probably of more importance than others.