I have zero interest in playing with this "2D screen inside VR" mode. That said, I have no problem switching between VR and an actual 2D monitor. I already do this with exploration, since the FSS is just a big floating 2D display drawn in front of me, so I'd rather use the FSS from the comfort of a high-res proper 2D display rather than a low-res box strapped to my head, switching to VR if I find something of particular interest that I wish to experience immersively. And since switching between 2D and VR is basically just a relog, something people do (not me) 100 times an hour to farm mats, so I don't see it as that big a deal.
I'm much more worried about what the performance of Odyssey will do to my personal VR experience, because low framerate does make me literally sick.