I have the CH Throttle, I bought it for ED along with the CH Fighterstick and I've been pretty happy with them, though I've never used other throttles so can't compare.
Buttons and 4 way hats are well placed for my hands and the mini joystick is great for vertical and lateral thrusters and tuning in the FSS, but I've had to add a little deadzone for the ministick.
Throttle movement is ok in feel, but if I look at the CH Control Manager, the throttle Z-axis value tends to jitter a bit and the throttle sometimes "sticks" in-game and doesn't go full throttle or 0 throttle, lifting the throttle unit and putting it back down usually "fixes" this. It seems that this jitteriness and "stickiness" is usually fixed by spraying the pot with contact cleaner and/or soldering the pot connections, which apparently are just clamped. I've meant to do these fixes for a while, but I've yet to reach the threshold of irritation to actually do something about it. I'll do it in the next 40 years, promise.
I don't have control manager installed - everything works just great without - ED and flight sims. (I use Fighterstick and Throttle in ED - I also have Yoke and pedals used in sims - all connected all the time and no issues.)