hey folks,
just wanted to give some sort of "final report" to this. I've done a few ten flight hours since the OT arrived, and I am very pleased. I have more or less memorized (well, muscle memorized) most of my button bindings, and I have to think less and less about the 6DoF movement.
In the end I stayed with the usual roll/pich/yaw on the right stick, and I settled on lateral on X, vertical on Y and fwd/reverse on the twist for the left stick. I also make heavy use of the preset thrust bindings (0/25/50/75/100), which I have on the right thumb 4-way (100% on the click).
I flew what feels like a million evac missions, so being quick on the approach and not botching the landing too much was important, and after a while it worked pretty well. I also went for some core mining, because that is where I learned the 6DoF movement in the first place - nothing like circling an asteroid

.
My final setup for the left stick were heavy springs and pretty loose clutches. Together with using the preset thrust bindings for cruising, I can fly for hours on end without my wrist hurting. The twist has also by now loosened up a bit (and doesn't make the "squish" noise anymore), so it is quite comfortable to hold the twist in one position for a time.
I am also very pleased that I have more than enough buttons for bindings and needed almost no modifier bindings to have everything as logically set as my brain wants it.
I am very satisfied, 10/10, would buy again

. For those interested, I published my bindings on
EDRefCard.
Thanks for your help and input!