I still play exclusively in VR, except for a very brief period where I tried my hand at settlement raiding, which I did on the flat screen. I switched to pretty much Odyssey only some time ago, don't remember after which update. I's been a good while, I haven't played in Horizons in many months.
Performance is okayish, but not great. I play with a first generation Reverb G2 on a Ryzen 9 5900X and a 3080 Ti with a mix of mostly high to ultra settings. After a lot of fiddling I settled on a SteamVR resolution setting of 60%, this gives me stable 90 fps in space and a guaranteed low limit of 45 fps (motion smoothing) with alot of assets on screen (stations, HazRes, Horizons settlements) while still looking good. Higher resolutions than 80% don't seem to give me that much of a benefit anyway, the edge blurring of the lenses is pretty much masking any gain in sharpness by upping the resolution.
I don't do Odyssey missions, CZs or other on foot stuff; last time I visited an Odyssey settlement was before update 12, I think. I might check it out again, but I'm sure I will still get drops below 40 or even below 30 fps in busy ones. Also, I guess I lose some performance headroom by using the HUD mod, but at this point it's essential for me. Also, i have set up Voice Attack, more for the company of two HCS voice packs (Kate and Ad-Astra) than controlling the ship, plus I use the npc vocalizer to have the npc chat spoken out. I hate that word, but it's very immersive that way.
it's not great performance wise, but I still enjoy the game immensely. I really enjoyed the Azimuth finale; I was in system and experienced the shutdown sequence and subsequent thatgoid attack in VR and was genuinely scared. Right now I'm out in the black towards the Eta Carinae nebula, having fun in my exploration dolphin. Flying in VR in Elite is just awesome, and I really like landing on atmospheric planets.
I think I would not play ED if it wasn't for VR. Truth is, I discovered ED only when I got my first headset and was looking for VR titles that would suit me. The first time I sat in the sidewinder in VR hooked me completely; it wouldn't have done in 2D.