The initial update SU5 was a disaster for quite a few people by all accounts - myself included as after it I couldn't fly, constant CTD's.
A total uninstall / reinstall fixed it, thankfully and I was able to get back into the cockpit - but at 124GB, this isn't something you want to have to do too often. The updates are big enough... Took me 5 hours and I have a 100 MB/s connection.
Having gingerly added the couple of mods I use back in, and they seem to be working pretty much Ok (I love the Working Title mods for the Garmins and the CJ4 - VNAV rules the skies

) I was pretty unimpressed with the graphical quality, seems quite a downgrade IMHO, but I have been able to set quite a few settings higher than they were and am getting acceptable performance (in VR with a Reverb G2) and it improved the graphics somewhat.
The new UI is also a bit naff, but by turning off all the tips and even the labels, it's workable. And actually, turning off all the labels means you have to actually know where the switches you need to use are.
As for Odyssey, that's much sadder for me. I've been playing ED since beta, sunk countless hours into it, have a lovely fleet of 30 odd ships, and honestly I never wanted space legs, and certainly not the way they implemented it (FPS pew pew - oh and I play in VR), and now I can hardly bring myself to log in Horizons, as I really wanted something new to do...
Now, if they implement VNAV for the spaceships, maybe that would do it...