All impact points so far have been uninhabited systems with an AW on the edge of the inhabited bubble. The second and third were exactly to the systems predicted earlier on this thread, too, once the first got a hint as to what to look for, which makes me more confident about the remaining five predictions.
The impact points (or projected impact points, for the remaining five) are not symmetrically distributed at all - they are largely on the "south" side of the bubble and far more are below the Sol plane than above it.
"Significant" depends on what you mean - none of them are likely on initial attack to hit any superpower capitals, powerplay headquarters, engineer systems or otherwise really obvious systems.