In response to the OP, about half of my friends lists are PvP players and outlaws which I am not. Funny thing is they are all nice people who simply enjoy the game differently than me. They like playing the outlaw and enjoy the rush of PvP combat, and while their victims may not like it, they generally try to do it in a friendly manner, and we have many mutual friends in common who met them by being victims.
While not my type of game, I respect their decision to play that way and understand why they enjoy it rather than the way I enjoy and play the game. On the whole they have no problems with me playing the game I like to play either, which is why we are friends. I would not have met any of them if not in open though.
Admittedly some of the reactions they have received from their in game "victims" crosses a line for me, and I'm left wondering why they don't target those "victims" more, particularly as after the abuse they have given by that "victim" for playing a legitimate part of the game I would be tempted to.
For the rest of my friends list, there are a lot of old rifters on there, but the rest are other players who play in open that I have met along the way, including members of the local PMFs around where I call home. Many of these are also purely PvE players, some both, and a few PvP. But if I hadn't been playing in open I wouldn't have met them, or joined random unknown people killing thargoids who became friends.
As to the game I play, well i spend a lot of time on BGS, and there if you come up against another player supported faction then you are still playing against other players and trying to beat them. In that I think it's appropriate that you can be caught playing against people and they can take direct action to stop you, rather than at a click of a button being anonymous and safe from any reprisal. Not being too much of a hypocrite (well most of us to some extent

) as I hate the anonymous attackers hiding in solo/PG to hurt somebody else's game, I don't do it myself. This means playing in Open.
And finally, once you get to a certain point NPCs are not really dangerous. You get to know depending on what you are flying when and how to kill them, and when and how you need to escape. That all falls into a predictable pattern, which lets admit it, with repetition just becomes boring and safe. As I'm supposed to be living in a wild dangerous galaxy, it needs open to provide that edge and the interest that comes with it.
Yes this means I have to deal with the occasional person I would rather have never met. Yes it means I get ganked and griefed at times. But the positive points and interactions I have had far outweigh them.
For anybody else choosing to play in open, if the people I prefer not to have met annoy you too much with their behaviour you always have the option to block, so there is still a way to play in open while only having to deal with griefers once. I would only caution that just because somebody ganks or pirates you, this doesn't mean that they are griefers. It's worth checking your comms and even talk to them first before you decide.
Should add, I do play in PG/Solo sometimes. PG to join friends who don't like open, solo when doing something that will just effect me and not others or the galaxy when I'm not in the mood for any company. If in a solo mood, I simply avoid the things that would impact on other players in any way.