As in, any activity or content that might become impossible to see or do once that 8th Titan falls?
Very hard to say.
If (which is highly unlikely!) Frontier plans to end the current Thargoid conflict with the destruction of Cocijo and put them back in the box for a few years, all the content surrounding them would no longer be available. It'd probably be easier to list what would be
left at that point
- you'd have various signal sources around Pleiades / Witch Head / California / Coalsack nebulae which could be entered for fights with Thargoid scouts and interceptors
- HIP 22460 would presumably continue to be itself
- since they haven't yet, several years on, it's unlikely the various attacked megaships, capital ships, etc. scattered around from before the war would be removed, and again Thargoid ships could be encountered there
- the
remains of the Spire sites would still be around the bubble
- Thargoid Barnacles and other surface sites could still be found in the nebulae
- the Titan wrecks would still be out there
All the rest is tied to the war simulation and would stop.
If that's not their plan, then no-one other than Frontier knows which bits will stick around, which bits will reappear in a different context, and which bits are just going.