Dr. Peter Drobac, Director of the Skoll Centre for Social Entrepreneurship at Oxford Saïd Business School, said that despite the rarity of the blood clots in both AstraZeneca and Johnson & Johnson's vaccines, any adverse effects could worsen vaccine hesitancy and even misinformation.
"It may fuel conspiracy theories around the world about a two-tiered society. If wealthy countries say they are only going to have 'gold standard' with the most expensive vaccines and then say AstraZeneca is not good enough for us in the global north, but it is good enough for the global south, it could reduce uptake of the vaccine and hamper efforts to vaccinate the world," he told CNN.
By this point, we already have this problem.
The thing that creates the most equality is oddly the virus. It will remorselessly kill humans of any station. It's humans that treat each other unfairly.
This old info is making the rounds in my circles:
Intravenous (i.v.) delivery of recombinant adenovirus serotype 5 (Ad5) vectors for gene therapy is hindered by safety and efficacy problems. We have discovered a new pathway involved in unspecific Ad5 sequestration and degradation. After i.v. ...
www.ncbi.nlm.nih.gov
Published online
2007 Feb 14.
Intravenous (i.v.) delivery of recombinant adenovirus serotype 5 (Ad5) vectors for gene therapy is hindered by safety and efficacy problems. We have discovered a new pathway involved in unspecific Ad5 sequestration and degradation. After i.v. administration, Ad5 rapidly binds to circulating platelets, which causes their activation/aggregation
Thrombocytopenia has been consistently reported following the administration of adenoviral gene transfer vectors. The mechanism underlying this phenomenon is currently unknown. In this study, we have assessed the influence of von Willebrand Factor (VWF) and P-selectin on the clearance of...
pubmed.ncbi.nlm.nih.gov
2007 Apr 1
Thrombocytopenia has been consistently reported following the administration of adenoviral gene transfer vectors. The mechanism underlying this phenomenon is currently unknown. In this study, we have assessed the influence of von Willebrand Factor (VWF) and P-selectin on the clearance of platelets following adenovirus administration.
So, for the last THIRTEEN years it has been known that adenoviruses mess with platelets?
Now I didn't know that. ( Had to work it out around last week - you might remember the confusing posts.) But you would think that if Oxford, AstraZeneca and Johnson & Johnson are going to make vaccines, they might have oh, IDK, looked up if adenoviruses cause any harm before deciding to use them to transport viral proteins? Testing in the trials showed no major issues, except a LOWER rate of clots, confirming functionally low platelets.
So why the odd cases where it's a big issue? If you read the little quotes above the answer is there: I.V. administration.
Can't say this better than Dr. Campbell.
Source: https://youtu.be/WuyAtvwP2H4?t=244
If he's correct, simply changing injection
technique might just solve the problem. Just ask your nurse to
aspirate please.
I'd posted that
low doses of the vaccine in the bloodstream would cause a drop in platelet count before, based on the physiology I knew. Diffusion from muscle to bloodstream would do that.
But if somehow the whole dose is going all at once into a vein, well, ha, that's not a small dose. That's millions of millions of molecules. And it will totally clog the platelets somewhere. Consistent with what we are seeing. It will only happen rarely, to unlucky people if no aspiration step is taken during the shots. This is exactly the same as any other IM injection- put it in the vein by mistake, and you are going to get trouble.
Europe is going to select other vaccines, the US will likely do the same, supply will flow like the Spice to us. This info is waay too complicated for the average layman to follow, and the disinformation is likely to outpace it. WHO guidelines say no aspiration is needed, and that ain't changing fast, nor is the average vaccinator going to catch on quick.
I'll just give the shots to my own family myself.
www.standard.co.uk
