The last time I set up 3 monitors I needed 2 cards this left one output free as there were 2 per card. If it can be done with one I'd like to know how.
660Gtx as previously said (or an ATI equivalent) is probably a good floor.
The newer cards have 4 outputs the Nvidias can run 4 at once (but only span the game across three, the other will just be your desktop unless you give it something else to do)
The ATIs apparently have 4 outputs but can only do 3 at once although that may have changed now with the newer cards.
i have three screens active, 1 is running from HDMI and the other 2 are running DVI (you need the cables without the 4 analogue pins, look for DVI-D on the packet)
There is also a Displayport socket, but none of my monitors have the right input for that. i know little about display port other than you can run multiple monitors off one socket if the monitors have daisy chain sockets, the video card still has a limit to how many it can drive though so you can't add extra screens over that limit.
Nvidias included software will sort out spanning your desktop and games across all three monitors however if you have odd sized monitors it will set them all to the smallest ones resolution, better to have them all the same size or you have to do what i do and run games windowed and stretched.
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