Yes, major gravitational effects from Black Holes if you get too close. More damage from mis-judging Neutron & White Dwarf Stars. Have certain stars throw out solar ejecta that needs dodging-& have passing too close to a star cause more damage too. Also, more natural phenomena in space that can cause problems to your ship.
The need for routine maintenance (whether ad hoc by the Commander, or done properly by a facility) would also be good.
I'd like to see some acknowledgement of radiation threats in space and particularly around planets, especially large planets!
[video=youtube_share;2FLOPlCYfz0]https://youtu.be/2FLOPlCYfz0[/video]
More details in this video.
[video=youtube_share;ka6OERznXh4]https://youtu.be/ka6OERznXh4[/video]
Currently, the game completely ignores these kind of issues!