I've made a few short (and admittedly glip responses) in this thread. However, when I read about 2.5kcr per ton runs it pretty much blows me away. From my persepective, that level of profit is, essentially, hitting the motherload. That's the region of megabucks max profit runs and if you hit it, then major bows to you, especially if you've hit it under your own steam and not used 3rd party insta-win plug ins.
I'm currently many light years away from my standard run but I do have a friend who has run it since the change. I have a home system and started looking for viable trade routes. I found a 3 system trade route that I fine tuned over time. I wasn't looking for the max cash I could find, just a profitable and enjoyable trade route. I managed to find it, 200kcr per lap of the 3 systems. Now, since the change, Palladium profits have gone down from the smaller station we used, but Gold has gone up beyond Palladium profits as we never traded it. The other systems have an estimated 4-8 different options of commodity trading, including a 4th station and a further 2 nearby systems that we could extend to should supply run dry.
My point is, you don't need to make ALL the profit to be making good profit. We have options and alternatives, along with an ever increasing set of trade options as we visit other local systems and learn who takes what and where.
Our 500-1Kcr per ton trade routes may seem meagre to some but there's a lot of enjoyment from switching/experimenting with commodities, not to mention the vast amount of supply missions that pop up at my home base which keep things interesting. Last I was there before exploring, I was running about 12 supply missions consecutively, this was quite enjoyable as it gave an entertaining amount of interaction to the station to station journey.
It may not be for everyone, and if you can't escape the credit Skinner box then it wont help, but shift your perspective slightly out of that and the rewards are far more transcendent.
Edit: Since running this trade route, my home faction has also increased by 3-4% which, being run between two people, is a satisfying change.