Sure. Quite a lot, to be honest. They're just a little awkward to reach while you have both hands on the controller...
I'm still using the DS4 controller (and sofa) from my console days, I think I've found a way to do just about everything I want with 2-button combinations and long holds. Had to make some compromises of course - I mapped one button to cycle through grenade types, rather than have different buttons for different types, for example.
I use a mini wireless keyboard for things like typing in the galaxy map though - I wearied of navigating around the letters on the virtual keyboard.