I upgraded my Hotas-X to a F16000 + the FCS Throttle (Thrustmaster). The H-X served me well, and is still used by one of my sons.
This combo is really pretty sweet--the throttle is amaze-sauce, buttons are perfectly placed and the throttle itself is smooth as silk. The joystick doesn't feel *that* amazing, but it's very accurate (then again, compared to the H-X, everything is accurate!). Base buttons are plentiful, but require use by the opposite (throttle) hand to operate unless you're taking your hand off the stick.
Had this setup now for a couple of months, and they're still working flawlessly. My only two gripes: the light on the stick is ridiculous, and I wish I could turn it off. The throttle has no lights at all, and you can't tell by looking at it if it's actually on. Normally, that's not an issue, but I've found the throttle to occasionally disconnect (never in-game, just between play sessions). This may also be an issue with my computer, but I have plugged it in several different usb ports with no change. Pretty rare, though--happens maybe once every two weeks.