Yes.
Playing in VR. Performance went up in H3.8 when I switched from 1080 TI to 6800 XT. AMD driver works when using the "recommended" version (not going to look up the version number now). Performance went down again - but not quite that much (purely subjective, and I never did and don't intend to do exhaustive numeric testing) - when going from H3.8 to H4.0. I like the new graphics look. I can land at (some?) Ody settlements - haven't yet consciously checked if I can land on "sparse atmosphere" worlds. New Galmap and Sysmap UI will take some getting used to, but isn't necessarily worse.
Jackson's Lighthouse looks much more impressive, but still supercharges as before.
No issues with bindings - I just downloaded and started into H4.0, all my usual keybinds still seem to be where I would expect them.
In short, so far: painless transition, better looking graphics, noticeable, but not too bad, performance hit.