YES!!
It makes all the difference in the world! I own the Saitek x55 Rhino, and I don't have to go to the keyboard for anything except sending messages during flight ops. When dogfighting, I have my thrusters mapped to a multidirectional switch on the throttle. This allows me to keep my guns on target, while doing F/A off maneuvers. I promise you with experience, you can tell which PC pilots are using mouse/keyboard by their flight characteristics. Joystick pilots will always get the most out of their craft, and will be the most deadly in pvp. I can quickly hit a switch to correct any flight condition (Hardpoints out/in, Landing gear, scoop, etc), without my hands leaving the stick/throttle. I promise, once you get used to playing this way, you won't go back!